這幾年由於血糖藥的 CV safety trials 的結果陸續發表，算是糖尿病界非常蓬勃發展發展的時間（要唸的書更多了@@）。不過除了糖尿病，還有內分泌疾病相關藥物的發展其實也默默地進行。

我們就趁此機會來回顧去年（2017）美國 FDA 通過了哪些本科相關藥物（看有哪些東西沒念到的！）。

算起來共 10 種藥，糖尿病才 4 種！

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1. Etelcalcetide（Parsabiv™）

Date of approval：2017/02/07

Mechanism：Calcium-sensing receptor agonist

Indication：secondary hyperparathyroidism in adults patients with chronic kidney disease on hemodialysis.

Company：KAI PHARMS INC

 

2. Dapagliflozin/Saxagliptin（10/5） combination（Qtern ™）

Date of approval：2017/02/27

Mechanism：SGLT2 inhibitor and DPP4 inhibitor

Indication：adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who have inadequate control with dapagliflozin or who are already treated with dapagliflozin and saxagliptin.

Company：ASTRAZENECA AB

 

3. Deflazacort（Emflaza ™）

Date of approval：2017/02/09

Mechanism：corticosteroid

Indication：for the treatment of Duchenne muscular dystrophy (DMD) in patients 5 years of age and older

Company：PTC THERAP

 

4. Telotristat ethyl（Xermelo ™）

Date of approval：2017/02/28

Mechanism：Tryptophan hydroxylase inhibitor

Indication：for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog（SSA） therapy in adults inadequately controlled by SSA therapy.

Company：LEXICON PHARMS INC

 

5. Abaloparatide（Tymlos ™）

Date of approval：2017/04/28

Mechanism：human parathyroid hormone-related peptide （PTHrP（1-34））analogue

Indication：for the treatment of postmenopausal women with osteoporosis at high risk for fracture defined as a history of osteoporotic fracture, multiple risk factors for fracture, or patients who have failed or are intolerant to other available osteoporosis therapy

Company：RADIUS HEALTH INC

 

6. Triptorelin（Triptodur ™）

Date of approval：2017/06/29

Mechanism：gonadotropin-releasing hormone (GnRH) agonist

Indication：for the treatment of pediatric patients 2 years and older with central precocious puberty

Company：Arbor Pharmaceuticals, LLC

 

7. Exenatide extended-release（Bydureon BCise ™）

Date of approval：2017/10/20

Mechanism：GLP-1 receptor agonist

Indication：adjust to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Company：ASTRAZENECA AB

 

8. Semaglutide（Ozempic ™）

Date of approval：2017/12/05

Mechanism：GLP-1 receptor agonist

Indication：adjust to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Company：NOVO NORDISK INC

 

9. Macimorelin（Macrilen）

Date of approval：2017/12/20

Mechanism：growth hormone (GH) secretagogue receptor agonist

Indication：for the diagnosis of adult growth hormone deficiency.

Company：Aeterna Zentaris Inc.

 

10. Ertugliflozin（Steglatro ™）

Date of approval：2017/12/19

Mechanism：SGLT2 inhibitor

Indication：adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Company：MERCK SHARP DOHME